• Ana Karine Vieira, Cristina Gonçalves Alvim, Clara Polito Braga, Ricardo Reis Dinardi, Marcos Vinícius Domingues Borba, Ricardo Manoel Oliveira Rodrigues, and Cássio da Cunha Ibiapina.
• Hemominas Foundation, Master's Degree in Pediatrics - Belo Horizonte (MG), Brazil.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (10): e20210819e20210819.

ObjectiveSickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nasal inspiratory flow measurements of children and adolescents with sickle cell disease.MethodsThis is a case-control study on children aged between 8 and 15 years who were diagnosed with sickle cell disease. Peak nasal inspiratory flow measurements were obtained from patients.ResultsA total of 279 patients were enrolled in this study, with 93 in the case group and 186 in the control group. The case group had an 82.83% chance of having lower peak nasal inspiratory flow values than the control group. In the case group, 75% of the peak nasal inspiratory flow values were in the lower standards, whereas in the control group, only 25% were in the lower standards.ConclusionThis study showed a high prevalence of reduced peak nasal inspiratory flow values in children with sickle cell disease and could certainly be incorporated into the day-to-day clinical evaluation of patients as a screening instrument.

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