• Muhammad Naeem, Till Ittermann, Marcello Ricardo Paulista Markus, Mohammed Farah Mahmoud Mousa, Laura von Heder, Robin Bülow, Marcus Dörr, Matthias Nauck, Ali Agdassi, Florian H Heidel, and Henry Völzke.
• Institute for Community Medicine, University Medicine Greifswald, Germany.
• Ups. J. Med. Sci. 2023 Jan 1; 128.

BackgroundThe aim of our study was to investigate associations of spleen volume with blood count markers and lipid profile in the general population.Materials & MethodsCross-sectional data from 1,106 individuals aged 30-90 years from the population-based Study of Health in Pomerania (SHIP-START-2) were analyzed. Blood count markers included red blood cell (RBC) counts, hemoglobin, platelet count, and white blood cell (WBC) counts. Lipid profile included total-cholesterol, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) as well as triglycerides. Linear regression models adjusted for age, sex, body height, and weight were used to associate standardized spleen volume with blood counts and lipid profile markers.ResultsSpleen volume was positively associated with RBC (β = 0.05; 95% confidence interval [CI] = 0.03 to 0.08) and hemoglobin (β = 0.05; 95% CI = 0.01 to 0.09) but inversely with platelet count (β = -16.3; 95% CI = -20.5 to -12.1) and WBC (β = -0.25; 95% CI = -0.37 to -0.14). Furthermore, spleen volume showed inverse associations with total cholesterol (β = -0.17; 95% CI = -0.24 to -0.09), HDL-C (β = -0.08; 95% CI = -0.10 to -0.05), and LDL-C (β = -0.12; 95% CI = -0.17 to -0.06). There was no significant association of spleen volume with triglycerides.ConclusionOur study showed that the spleen volume is associated with markers of the blood count and lipid profile in the general population.© 2023 The Author(s). Published by Upsala Medical Society.

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