• J Chin Med Assoc · Dec 2023

    Sex and Age Differences of Major Cardiovascular Events in Patients After Percutaneous Coronary Intervention.

    • Ya-Ling Yang, Su-Chan Chen, Cheng-Hsueh Wu, Shao-Sung Huang, Leong ChanWanWDepartment of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Shing-Jong Lin, Chia-Yu Chou, Jaw-Wen Chen, Ju-Pin Pan, Min-Ji Charng, Ying-Hwa Chen, Tao-Cheng Wu, Tse-Min Lu, Pai-Feng Hsu, Po-Hsun Huang, Hao-Min Cheng, Chin-Chou Huang, Shih-Hsien Sung, Yenn-Jiang Lin, and Hsin-Bang Leu.
    • Department of Cardiology, Cardinal Tien Hospital, New Taipei City, Taiwan, ROC.
    • J Chin Med Assoc. 2023 Dec 1; 86 (12): 104610521046-1052.

    BackgroundWomen usually have higher risk after receiving percutaneous coronary interventions (PCIs) than men with coronary artery disease (CAD). The aim of this study was to investigate the association of sex differences with future outcomes in CAD patients undergoing PCI, to assess the role of age, and to extend observed endpoints to stroke and congestive heart failure.MethodsSix thousand six hundred forty-seven patients with CAD who received successful PCIs. The associations between clinic outcomes and sex were analyzed. The primary outcome was major cardiovascular events (MACE), including cardiac death, nonfatal myocardial infraction, and nonfatal stroke. The secondary outcome was MACE and hospitalization for heart failure (total CV events).ResultsDuring a mean of 52.7 months of follow-up, 4833 men and 1614 women received PCI. Univariate and multivariate analyses showed that women were independently associated with an increased risk of cardiac death (HR, 1.78; 95% CI, 1.32-2.41), hospitalization for heart failure (HR, 1.53; 95% CI, 1.23-1.89), MACE (HR, 1.34; 95% CI, 1.10-1.63), and total CV events (HR, 1.39; 95% CI, 1.20-1.62). In the subgroup analysis, women aged under 60 years had higher cardiovascular risks than men of the same age category.ConclusionWomen with CAD after successful PCI had poorer cardiovascular outcomes than men. Additionally, younger women (aged <60 years) were especially associated with a higher risk of developing future adverse cardiovascular outcomes.Copyright © 2023, the Chinese Medical Association.

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