• Gema Ramírez-Rodríguez, Antonio Menéndez-Lobo, Alejandro Romero-Linares, Miriam Bernabéu-Fernández de Liencres, Pedro Jose Romero-Palacios, Bernardino Alcázar-Navarrete, and “Spanish COPD mortality study group”.
• Respiratory Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. Electronic address: gemaramirezrodriguez@hotmail.com.
• Med Clin (Barc). 2024 Jan 12; 162 (1): 9149-14.

IntroductionMortality from COPD has decreased in Spain in recent years, but it is unknown whether this decline has been homogeneous among the different regions.MethodsFrom the Statistical Portal of the Ministry of Health of Spain we obtained the age-adjusted mortality rates/100,000 inhabitants for men and women in Spain and the Autonomous Communities for the years 1999-2019, using the coding of the International Classification of Diseases (ICD 10, sections J40-J44). With the adjusted rates we performed a jointpoint regression analysis to estimate an annual percentage change (APC), as well as identify possible points of trend change. Statistical significance was considered for a value of p<0.05.ResultsDuring the study period, COPD mortality rates adjusted in Spain decreased from 28.77 deaths/100,000 inhabitants in 1999 to 12.14 deaths/100,000 inhabitants in 2019. We observed a linear decline in COPD mortality in men at national level of -3.67% per year (95% CI -4.1 to -3.4; p<0.001), with differences between the Autonomous Communities. Mortality in women also experienced a decrease in mortality in two phases, with a first period from 1999 to 2006 with a fall of -6.8% per year (95% CI -8.6 to -5.0; p<0.001) and a second period from 2006 to 2019 with a decrease in mortality of -2.1% (95% CI -2.8 to -1.3; p<0.001), with again differences between the Autonomous Communities.ConclusionMortality rates from COPD have decreased heterogeneously among the different Autonomous Communities in both men and women.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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