Needle in a haystack: localising the long-term neuronal changes

Br J Anaesth · Dec 2023

Editorial Comment

Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia.

Narrowing down the histopathological changes in the brain after early-life exposure to general anaesthesia has presented a consistent challenge for preclinical models of anaesthetic neurotoxicity. Using resting-state functional magnetic resonance imaging, in this issue of the journal Neudecker and colleagues demonstrated in vivo connectivity changes in the brain following a seed-based analysis that was derived from previously reported histopathology in the same animals. The combination of neurohistology and neuroimaging should help focus future preclinical studies investigating the developmental consequences of early exposure to general anaesthesia.

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- Greena Kim, Alison R Weiss, and Jessica Raper.
- Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
- Br J Anaesth. 2023 Dec 1; 131 (6): 975977975-977.
AbstractNarrowing down the histopathological changes in the brain after early-life exposure to general anaesthesia has presented a consistent challenge for preclinical models of anaesthetic neurotoxicity. Using resting-state functional magnetic resonance imaging, in this issue of the journal Neudecker and colleagues demonstrated in vivo connectivity changes in the brain following a seed-based analysis that was derived from previously reported histopathology in the same animals. The combination of neurohistology and neuroimaging should help focus future preclinical studies investigating the developmental consequences of early exposure to general anaesthesia.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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Needle in a haystack: localising the long-term neuronal changes from early-life exposure to general anaesthesia.

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