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- Eo Toriyama, Yoshitaka Imaizumi, Kazuto Tsuruda, Hidehiro Itonaga, Shinya Sato, Koji Ando, Yasushi Sawayama, Hiroo Hasegawa, Tomoko Hata, Daisuke Niino, Katsunori Yanagihara, and Yasushi Miyazaki.
- Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan.
- Intern. Med. 2019 Aug 1; 58 (15): 221322172213-2217.
AbstractPlasma cell leukemia (PCL) is a rare variant of multiple myeloma. The detection of plasma cells in the peripheral blood and monoclonal protein in the serum or urine is important for the diagnosis of PCL. However, it is sometimes difficult to diagnose PCL in patients with atypical plasma cell morphology and/or those without detectable monoclonal protein. We herein report a case of oligosecretory PCL showing atypical morphology in leukemic cells with a convoluted nucleus and basophilic cytoplasm but without detectable monoclonal protein, except for serum free light chain. A flow cytometric analysis and pathological analysis were useful for the early diagnosis of PCL.
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