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- Yuki Kitazaki, Osamu Yamamura, Kojiro Usui, Asako Ueno, Sayaka Sanada, Hirohito Sasaki, Yoshinori Endo, Soichi Enomoto, Masamichi Ikawa, Yasunari Nakamoto, and Tadanori Hamano.
- Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan.
- Intern. Med. 2023 Jan 1; 62 (20): 301330203013-3020.
AbstractNivolumab blocks inhibitors of T-cell activation and restores antitumor immunity but promotes T-cell activity in host tissues by blocking inhibition of the T-cell function, resulting in immune-related adverse effects. We herein report an 80-year-old man presenting with nivolumab-related myasthenia gravis with anti-muscular voltage-gated potassium channel-complex (Kv1.4) antibodies. On day 29 after nivolumab administration, he simultaneously developed rapidly progressing right ptosis and left facial paralysis. Nivolumab administration was discontinued. He subsequently presented with bulbar paralysis, dyspnea, and muscle weakness and received intravenous immunoglobulin, methylprednisolone, and plasma exchange. The severity of nivolumab-related myasthenia gravis with anti-Kv1.4 antibodies presented with diverse clinical findings.
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