• Xiaoying Li, Yuehong Xu, and Pu Liao.
• Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
• Clinics (Sao Paulo). 2023 Jan 1; 78: 100290100290.

BackgroundIn recent years, more and more studies have shown that microRNA-29a (miRNA-29a) can be used as a potential biomarker for active tuberculosis, but the results of these studies are not consistent.ObjectiveTo comprehensively evaluate the value of miRNA-29a in the diagnosis of active tuberculosis by meta-analysis.MethodsThe databases of CNKI, WanFang, PubMed, The Cochrane Library, Web of Science and EMBASE were searched for relevant studies. Studies were screened strictly according to inclusion and exclusion criteria. QUADAS-2 scale was used to evaluate the quality of the included studies. Data were extracted and analyzed by Meta-DiSc 1.4 and Stata 16.0 software.Results13 articles were included, including a total of 1598 subjects, including 872 active tuberculosis patients and 726 controls. The combined sensitivity and specificity of miRNA-29a in the diagnosis of active tuberculosis were 78 % and 76 %, respectively, and the area under the overall summary receiver operating characteristic curve was 0.8564.ConclusionmiRNA-29a can be used as a biomarker for the diagnosis of active tuberculosis.Copyright © 2023. Published by Elsevier España, S.L.U.

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