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- Yuki Nakayama, Masayuki Yamanouchi, Hiroki Mizuno, Tatsuya Suwabe, Akinari Sekine, Daisuke Ikuma, Eiko Hasegawa, Yuki Oba, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Takehiko Wada, Naoki Sawa, and Yoshifumi Ubara.
- Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan.
- Intern. Med. 2024 May 15; 63 (10): 142914321429-1432.
AbstractA 35-year-old woman was admitted for the examination of lower leg edema and proteinuria. A kidney biopsy showed membranous nephropathy (MN) with fine granular deposits of IgG along the glomerular capillary and poor spike formation, differing from primary MN in the presence of positive IgG3 and C1q. Lupus nephritis was excluded because serum complement and anti-dsDNA antibody, anti-Smith antibody, and anti-cardiolipin antibody tests were negative. The serological test for syphilis was positive, as was the Treponema pallidum hemagglutination test. The patient was diagnosed with syphilis, and the proteinuria disappeared with antibiotic treatment. In MN with positive IgG3 and C1q, syphilis nephropathy may be a differential diagnosis.
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