• Edilberto Amorim, Wei-Long Zheng, Mohammad M Ghassemi, Mahsa Aghaeeaval, Pravinkumar Kandhare, Vishnu Karukonda, Jong Woo Lee, Susan T Herman, Adithya Sivaraju, Nicolas Gaspard, Jeannette Hofmeijer, van PuttenMichel J A MMJAMClinical Neurophysiology Group, University of Twente, Enschede, The Netherlands.Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, The Netherlands., Reza Sameni, Matthew A Reyna, Gari D Clifford, and M Brandon Westover.
• Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
• Crit. Care Med. 2023 Dec 1; 51 (12): 180218111802-1811.

ObjectivesTo develop the International Cardiac Arrest Research (I-CARE), a harmonized multicenter clinical and electroencephalography database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest.DesignMulticenter cohort, partly prospective and partly retrospective.SettingSeven academic or teaching hospitals from the United States and Europe.PatientsIndividuals 16 years old or older who were comatose after return of spontaneous circulation following a cardiac arrest who had continuous electroencephalography monitoring were included.InterventionsNot applicable.Measurements And Main ResultsClinical and electroencephalography data were harmonized and stored in a common Waveform Database-compatible format. Automated spike frequency, background continuity, and artifact detection on electroencephalography were calculated with 10-second resolution and summarized hourly. Neurologic outcome was determined at 3-6 months using the best Cerebral Performance Category (CPC) scale. This database includes clinical data and 56,676 hours (3.9 terabytes) of continuous electroencephalography data for 1,020 patients. Most patients died ( n = 603, 59%), 48 (5%) had severe neurologic disability (CPC 3 or 4), and 369 (36%) had good functional recovery (CPC 1-2). There is significant variability in mean electroencephalography recording duration depending on the neurologic outcome (range, 53-102 hr for CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in frequency for at least 1 hour was seen in 258 patients (25%) (19% for CPC 1-2 and 29% for CPC 3-5). Burst suppression was observed for at least 1 hour in 207 (56%) and 635 (97%) patients with CPC 1-2 and CPC 3-5, respectively.ConclusionsThe I-CARE consortium electroencephalography database provides a comprehensive real-world clinical and electroencephalography dataset for neurophysiology research of comatose patients after cardiac arrest. This dataset covers the spectrum of abnormal electroencephalography patterns after cardiac arrest, including epileptiform patterns and those in the ictal-interictal continuum.Copyright © 2023 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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