• Ludovico Abenavoli, Stefano Dastoli, Luigi Bennardo, Luigi Boccuto, Maria Passante, Martina Silvestri, Ilaria Proietti, Concetta Potenza, Francesco Luzza, and Steven Paul Nisticò.
• Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. l.abenavoli@unicz.it.
• Medicina (Kaunas). 2019 Sep 9; 55 (9).

AbstractCeliac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.

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