• Yunjuan Jiao, Fanming Meng, Gaoen Ma, Hetian Lei, and Junwen Liu.
• Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, China; Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, China.
• Clinics (Sao Paulo). 2023 Jan 1; 78: 100289100289.

IntroductionStable angina develops during physical activity or stress, and it is typically an aspect of Coronary Heart Disease (CHD) that can lead to arrhythmia, heart failure and even sudden death. ANRIL, an Antisense Noncoding RNA gene in the INK4 Locus, is associated with multiple disorders including CHD; however, expressional levels of ANRIL in between patients with stable angina and myocardial infarction, one of the acute coronary syndrome, have not been clarified yet.MethodsThe authors enrolled 62 patients with myocardial infarction and 59 with stable angina before primary percutaneous coronary intervention, as well as 48 healthy volunteers. Their peripheral blood was collected for analysis of ANRIL and cardiac troponin I, a traditional diagnostic index of CHD by real-time PCR.ResultsThe data showed that ANRIL is a better diagnostic indicator than cardiac troponin I in patients with stable angina and that the levels of ANRIL are higher in patients with stable angina than those with the myocardial infarction.DiscussionThe levels of ANRIL in peripheral plasma could be used as a good biomarker for stable angina.Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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