• World Neurosurg · Jan 2024

    Review Meta Analysis

    Effects of electrospun nanofibers on motor function recovery after spinal cord injury; a systematic review and meta-analysis.

    • Niloofar Haeri Moghaddam, Somayeh Hashamdar, Michael R Hamblin, and Fatemeh Ramezani.
    • Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    • World Neurosurg. 2024 Jan 1; 181: 9610696-106.

    AbstractNanofibers made by electrospinning have been used as bridging materials in animal models to regenerate nerves after spinal cord injury (SCI). In this meta-analysis study, we investigated the effect of these nanofibers on the motor function of animals after SCI. An extensive search in databases was performed. After primary and secondary screening, data included functional behavior, expression of glial fibrillary acidic protein, neurofilament-200 (NF-200), and β-tubulin III were taken from the articles. The quality control of the articles, statistical analysis, and subgroup analysis were performed. The results from 14 articles and 16 separate experiments showed that electrospun nanofibers used alone could improve motor behavior and reduce glial injury after SCI.Copyright © 2023 Elsevier Inc. All rights reserved.

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