• Rosana Gregori Sabelli, Yesica Lamberto, Pablo Saul, Natalia Campagnucci, Viviana Chediack, and Eleonora Cunto.
• Departamento de Terapia Intensiva-DAIPIC, Hospital de Infecciosas Francisco J Muñiz, Buenos Aires, Argentina. E-mail: roxygregori@gmail.com.
• Medicina (B Aires). 2023 Jan 1; 83 (5): 828831828-831.

AbstractMalaria is a wide-spread disease in tropical areas. The severe form is characterized by organic involvement and/or hyperparasitaemia. Criteria for early monitoring in intensive care rooms are defined; without a timely and early treatment, severe malaria has a 100% mortality. Although the literature in these cases is not extensive, extracorporeal therapy used sequentially for hepatic and renal detoxification is a useful and safe tool that can be used in intensive care. We describe the case of a 36-year-old man with a diagnosis of severe malaria according to WHO criteria. He began treatment with intravenous artesunate and due to a torpid evolution, a sudden increase in bilirubinemia with encephalopathy, parameters of acute kidney injury and acute pulmonary edema, undergoes extracorporeal sequential treatment, coupled with plasma filtration adsorption, high-exchange plasmapheresis, and continuous hemodiafiltration with favorable evolution. This case shows that extracorporeal support in trained hands and in a timely manner is effective when organ failure evolves rapidly to achieve stability and provide necessary time for definitive treatment, in this case rapid action antimalarials until parasitemia becomes negative.

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