• Damian Bruce-Hickman, Zhen Yu Lim, Huey Ying Lim, Faheem Khan, Shilpa Rastogi, Chee Keat Tan, and Clara Lee Ying Ngoh.
• Department of Intensive Care Medicine, Ng Teng Fong General Hospital, National University Health System, Singapore.
• Crit Care Resusc. 2023 Mar 1; 25 (1): 273227-32.

ObjectiveUltrasound shear wave elastography (SWE) is a novel technique that may provide non-invasive measurements of renal compliance. We aimed to investigate the relationship between intravenous (IV) fluid administration and change in SWE measurements. We hypothesised that following IV fluid administration in healthy volunteers, global kidney stiffness would increase and that this increase in stiffness could be quantified using SWE. Our second hypothesis was that graduated doses of IV fluids would result in a dose-dependent increase in global kidney stiffness measured by SWE.DesignRandomised prospective study.SettingIntensive Care Unit.ParticipantsHealthy volunteers aged 18-40 years.InterventionsParticipants were randomised to receive 20 ml/kg, 30 ml/kg, or 40 ml/kg of normal saline. The volume of fluid infused was based on the actual body weight recorded.Main Outcome MeasuresWe recorded average SWE stiffness (kPa with standard deviation of the mean), median SWE stiffness (kPa), and the interquartile range.ResultsNinety-eight percent of participants (44/45) demonstrated an increase in global kidney stiffness following administration of IV fluids. The average SWE pre fluid administration was 7.572 kPa ± 2.38 versus 14.9 kPa ± 4.81 post fluid administration (p < 0.001). In subgroup analysis, there were significant changes in global kidney stiffness pre and post fluid administration with each volume (ml/kg) of fluid administered. Average percentage change in global kidney stiffness from baseline was compared between the three groups. There was no significant difference when comparing groups 1 and 2 (197.1% increase ± 49.5 vs 216.1% ± 72.0, p ¼ 0.398), groups 2 and 3 (216.1% increase ± 72.0 vs 197.8% ± 59.9, p ¼ 0.455), or groups 1 and 3 (197.1% increase ± 49.5 vs 197.8% ± 59.9, p ¼ 0.972).ConclusionsFluid administration results in immediately visible and quantifiable changes in global kidney stiffness across all infused volumes of fluid.© 2023 Published by Elsevier B.V. on behalf of College of Intensive Care Medicine of Australia and New Zealand.

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