• Idunn S Morris, Thiago Bassi, Charissa Oosthuysen, and Ewan C Goligher.
• Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Department of Medicine, Division of Respirology, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; and Department of Intensive Care Medicine, Nepean Hospital, Sydney, Australia.
• Respir Care. 2023 Nov 25; 68 (12): 173617471736-1747.

AbstractDiaphragm inactivity during invasive mechanical ventilation leads to diaphragm atrophy and weakness, hemodynamic instability, and ventilatory heterogeneity. Absent respiratory drive and effort can, therefore, worsen injury to both lung and diaphragm and is a major cause of failure to wean. Phrenic nerve stimulation (PNS) can maintain controlled levels of diaphragm activity independent of intrinsic drive and as such may offer a promising approach to achieving lung and diaphragm protective ventilatory targets. Whereas PNS has an established role in the management of chronic respiratory failure, there is emerging interest in how its multisystem putative benefits may be temporarily harnessed in the management of invasively ventilated patients with acute respiratory failure.Copyright © 2023 by Daedalus Enterprises.

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