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Case Reports
Kidney Biopsy Proven Thrombotic Microangiopathy Induced by Methamphetamine: A Case Report.
- Kanako Nagaoka, Daisuke Katagiri, Masatoshi Matsunami, Miria Chinen, Kurumi Seki, Junko Fukuda, Mamiko Ohara, and Tomo Suzuki.
- Department of Nephrology, Kameda Medical Center, Japan.
- Intern. Med. 2024 Jun 1; 63 (11): 160316081603-1608.
AbstractA 47-year-old man was admitted to our hospital with acute kidney injury, severe hypertension, heart failure, thrombocytopenia, and elevated lactate dehydrogenase. Renal biopsy revealed fibrin thrombi within the glomerular capillaries and moderate fibrotic intimal thickening in the interlobular arteries. The histological diagnosis was thrombotic microangiopathy (TMA). Regarding cardiac involvement, we found marked stenosis in the left anterior descending artery on coronary angiography and cardiomyopathy on myocardial biopsy. Blood concentrations of amphetamine and methamphetamine were high (14.1 ng/mL and 333 ng/mL, respectively). It is important to consider methamphetamine as a cause of renal TMA and multi-organ dysfunction.
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