• Internal medicine · Jun 2024

    Case Reports

    Serum Cytokine Changes in a Patient with Chronic Pulmonary Aspergillosis Overlapping with Allergic Bronchopulmonary Aspergillosis: A Case Report.

    • Yusei Tsukamoto, Yuya Ito, Yasushi Obase, Takahiro Takazono, Nana Nakada, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Naoki Iwanaga, Masato Tashiro, Naoki Hosogaya, Susumu Fukahori, Chizu Fukushima, Katsunori Yanagihara, Koichi Izumikawa, and Hiroshi Mukae.
    • Department of Respiratory Medicine, Nagasaki University Hospital, Japan.
    • Intern. Med. 2024 Jun 1; 63 (11): 165916641659-1664.

    AbstractAllergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are diseases caused by Aspergillus infection, and CPA can develop from ABPA in some cases. We herein report a patient with CPA overlapping with ABPA. Serum cytokine levels were evaluated at 4 time points: the ABPA diagnosis, CPA diagnosis, 6 months after the start of voriconazole (VRCZ), and 12 months after re-administration of VRCZ. Interleukin (IL)-13 levels decreased upon glucocorticoid treatment, whereas IL-25 and IL-33 levels decreased rapidly with the initiation of antifungals. Early antifungal therapy may be important to control disease progression and prevent CPA overlap.

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