• Jinfei Su, Qinzhan Ren, Pu Li, Wei Wei, Junqi Liu, Yanjun Feng, Xu Huang, Yanxiang Cao, Wei Wang, Min Wu, Qiuhang Zhang, and Zhenlin Wang.
• Skull Base Surgery Center and Department of Otorhinolaryngology-Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
• World Neurosurg. 2024 Jan 1; 181: e493e503e493-e503.

BackgroundTo assist doctors in making better treatment decisions and improve patient prognosis, it is important to determine which therapy modalities are suitable for various forms of idiopathic hypertrophic cranial pachymeningitis (IHCP).MethodsAll cases were received from the hospital medical record system, and some follow-up information was gathered through telephone follow-up.ResultsA total of 26 patients, 14 men and 12 women, with ages ranging from 20 to 73 years and a mean of 47.42 years, were included in the research. Regular types were less likely to recur than irregular and nodular types, focal types were less likely to recur than diffuse types, and corticosteroid-refractory types were more likely to recur than corticosteroid-sensitive types.ConclusionsThe extent and shape of the lesion and susceptibility to corticosteroids are potential factors that could influence recurrence. Futhermore, this paper also proposes the fibroblasts as a new therapeutic target which may improve the quality of prognostic survival of patients.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

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