• R E Drysdale, W Slemming, D Momberg, R Said-Mohamad, and L M Richter.
• DSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg, South Africa. roisin.drysdale@wits.ac.za.
• S. Afr. Med. J. 2023 Oct 23; 113 (10): 374137-41.

BackgroundPregnant women were indirectly affected by the COVID-19 pandemic owing to heightened stress, fear of mother-to-child transmission of COVID-19 and the disruption of antenatal health services. Increased stress and lack of antenatal healthcare could result in an increase in adverse birth outcomes such as preterm birth or low birthweight.ObjectivesUsing a case-control design, to compare the prevalence of low birthweight among infants born before and during the pandemic in Soweto, South Africa.MethodInfants born before the pandemic and national lockdown were included in the control group, while infants who were in utero and born during the pandemic were included in the case group. Only infants born ≥37 weeks' gestation with no birth complications were included. Multivariable logistic regression was employed to determine whether the pandemic was associated with an increase in low birthweight. A birthweight <2.5 kg was classified as low birthweight.ResultsIn total, 199 mother-infant pairs were included in the control group, with 201 mother-infant pairs in the case group. The prevalence of low birthweight was 4% in the control group and 11% in the case group, with those born during the pandemic at a higher risk of being of low birthweight.ConclusionThe high prevalence of low birthweight in infants born ≥37 weeks' gestation during the pandemic could result in an increase in child stunting and poor development. Future research should measure early child development and growth in infants born during the pandemic to assess whether there is a need to intervene and provide additional support to minimise the negative effects.

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