• Gladys Rocha, Israel Podestá, and Andrea Canales.
• Centro Medico Endocrino, Clínica Santa María, Santiago, Chile.
• Rev Med Chil. 2022 May 1; 150 (5): 575583575-583.

BackgroundDiet and exercise are the mainstay of weight reduction programs.AimTo evaluate the effect of diet and exercise on body weight and composition and resting metabolic rate (RMR) in obese adults.Material And MethodsTwenty-eight obese adults aged 22 to 61 years (18 women) completed four months of diet and exercise. They attended monthly nutritional consultations, and two-three weekly exercise sessions. At baseline and the end of the intervention, anthropometry, body composition by bioimpedance and RMR by indirect calorimetry (IC) were measured. Metabolic adaptation, defined as a decrease in thermogenesis to an extent greater than predicted based on the change in body weight and composition, was calculated.ResultsSignificant reductions in body weight and fat mass were observed in both genders. Fat-free mass decreased in women and remained unchanged in men. RMR remained stable. Metabolic adaptation was observed in 11/27 participants. Fat mass change in participants with and without metabolic adaptation was 8 Kg and 4,4 kg, respectively (p = 0,018). In the linear regression analysis, male sex accounted for a higher RMR (247.80 Kcal, p = 0,006) than females. For each kg of fat and fat free mass, the RMR varies 7.25 Kcal, (p = 0.02) and 9.79 Kcal (p = 0,006), respectively.ConclusionsThe intervention reduced body weight and fat mass and maintained RMR. Fat free mass decreased in women. Participants with metabolic adaptation showed greater changes in fat mass.

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