• Ricardo Valjalo and María T Mallea.
• Hospital del Salvador, Servicio de Medicina Interna, Hospital del Salvador, Santiago, Chile.
• Rev Med Chil. 2023 Feb 1; 151 (1): 526052-60.

BackgroundThe frequency of glomerular diseases is dynamic and varies according to geographic area.AimTo evaluate the frequency of primary and secondary glomerulopathies, their demographic profile and main clinical characteristics.Material And MethodsRenal biopsies from native kidneys performed between 1999 and 2020 were retrospectively reviewed. Demographic characteristics, clinical presentation, most relevant laboratory tests, frequency of primary and secondary glomerulopathies were analyzed.ResultsWe analyzed 550 kidney biopsies from patients with a median age of 48 years (64% females). Nephrotic syndrome was the main indication for renal biopsy. Primary and secondary glomerulopathies occurred with similar frequency. Within the primary glomerulopathies, membranous nephropathy (34.1%) was the most common, followed by IgA nephropathy (31.1%) and focal segmental glomerulosclerosis (14.1%). Among the secondary glomerulopathies, lupus nephropathy was the most common (41.7%), followed by pauciimmune glomerulonephritis (27.1%) and diabetic nephropathy (6.4%). When comparing the results with other regions, significant differences were observed with reported frequencies in United States, Europe, Asia and the rest of Latin America.ConclusionsThe most common primary glomerulopathies were membranous nephropathy and IgA nephropathy. Among the secondary glomerulopathies lupus nephropathy and pauci-immune glomerulonephritis were the most common. Compared to international registries, we observed a high proportion of membranous nephropathy and pauci-immune glomerulonephritis.

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