• Vlad Iustin Tica, Iulia Postolache, Madalina Boșoteanu, Mariana Aschie, Irina Tica, Cristian Ionut Orasanu, Roxana Cleopatra Penciu, Andrei Adrian Tica, Liliana Steriu, Rudy Leon De Wilde, and Oana Sorina Tica.
• Department of Obstetrics and Gynecology, "Saint Andrew" University Emergency Hospital Constanta, Faculty of Medicine, Academy of Romanian Scientists University "Ovidius", 900527 Constanta, Romania.
• Medicina (Kaunas). 2023 Oct 10; 59 (10).

AbstractBackground: Osseous tissue in the endometrium is a rare find, and it is most often discovered when the patient presents with infertility. It is frequently associated with dysmenorrhea and abnormal menstrual bleedings. Although its etiology remains unclear, in almost all described cases until now, the patient has an obstetrical history. Case report: In this report, we present a unique case of endometrial osseous metaplasia in a 27-year-old primary infertile patient. The transvaginal ultrasound revealed a 18/13/7 mm hyperechoic endometrial mass with posterior acoustic shadowing and no flow on color Doppler. A hysteroscopic examination found a polygonal calcification on the endometrial posterior face of the uterine cavity, in the corporeal isthmic region, which was extracted. The histopathological evaluation revealed microscopic elements compatible with endometrial calcification. The patient had a good postoperative course and the complex endocrinologic, immunologic and electrolytical investigation failed to prove any abnormality. Follow-up transvaginal ultrasound examinations revealed no modifications. Three years later, the patient conceived spontaneously, had an uneventful pregnancy and delivered a full-term fetus. Conclusion: We assumed that this entity can be a serious cause of infertility since the patient had a long history of (primary) infertility and its resection made the pregnancy's occurrence possible. Finally, since neither history of abortion or chronic inflammation nor any abnormal laboratory test were noticed, we concluded that the etiology of this entity remained unclear.

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