• J R Soc Med · Apr 2024

    Adverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study.

    • Ruby Sm Tsang, Utkarsh Agrawal, Mark Joy, Rachel Byford, Chris Robertson, Sneha N Anand, William Hinton, Nikhil Mayor, Debasish Kar, John Williams, William Victor, Ashley Akbari, Declan T Bradley, Siobhan Murphy, Dermot O'Reilly, Rhiannon K Owen, Antony Chuter, Jillian Beggs, Gary Howsam, Aziz Sheikh, Richard HobbsF DFDNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.6396, and LusignanSimon deSNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.6396Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, UK.3527.
    • Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.
    • J R Soc Med. 2024 Apr 1; 117 (4): 134148134-148.

    ObjectivesTo estimate the incidence of adverse events of interest (AEIs) after receiving their first and second doses of coronavirus disease 2019 (COVID-19) vaccinations, and to report the safety profile differences between the different COVID-19 vaccines.DesignWe used a self-controlled case series design to estimate the relative incidence (RI) of AEIs reported to the Oxford-Royal College of General Practitioners national sentinel network. We compared the AEIs that occurred seven days before and after receiving the COVID-19 vaccinations to background levels between 1 October 2020 and 12 September 2021.SettingEngland, UK.ParticipantsIndividuals experiencing AEIs after receiving first and second doses of COVID-19 vaccines.Main Outcome MeasuresAEIs determined based on events reported in clinical trials and in primary care during post-license surveillance.ResultsA total of 7,952,861 individuals were vaccinated with COVID-19 vaccines within the study period. Among them, 781,200 individuals (9.82%) presented to general practice with 1,482,273 AEIs. Within the first seven days post-vaccination, 4.85% of all the AEIs were reported. There was a 3-7% decrease in the overall RI of AEIs in the seven days after receiving both doses of Pfizer-BioNTech BNT162b2 (RI = 0.93; 95% CI: 0.91-0.94) and 0.96; 95% CI: 0.94-0.98), respectively) and Oxford-AstraZeneca ChAdOx1 (RI = 0.97; 95% CI: 0.95-0.98) for both doses), but a 20% increase after receiving the first dose of Moderna mRNA-1273 (RI = 1.20; 95% CI: 1.00-1.44)).ConclusionsCOVID-19 vaccines are associated with a small decrease in the incidence of medically attended AEIs. Sentinel networks could routinely report common AEI rates, which could contribute to reporting vaccine safety.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…