• Kelsey M Gladen, David Tellez, Natalie Napolitano, Lauren R Edwards, Ronald C Sanders, Taiki Kojima, Matthew P Malone, Justine Shults, Conrad Krawiec, Shashikanth Ambati, Riley McCarthy, Aline Branca, Lee A Polikoff, Philipp Jung, Simon J Parsons, Palen P Mallory, Kavipriya Komeswaran, Christopher Page-Goertz, Megan C Toal, G Kris Bysani, Keith Meyer, Fabrizio Chiusolo, Lily B Glater-Welt, Awni Al-Subu, Katherine Biagas, Hau LeeJanJChildren's Intensive Care Unit, KK Women's and Children's Hospital, Singapore., Michael Miksa, John S Giuliano, Krista L Kierys, Andrea M Talukdar, Michelle DeRusso, Laurence Cucharme-Crevier, Michelle Adu-Arko, Asha N Shenoi, Dai Kimura, Molly Flottman, Shantaveer Gangu, Ashley D Freeman, Mark D Piehl, G A Nuthall, Keiko M Tarquinio, Ilana Harwayne-Gidansky, Tatsuya Hasegawa, Erin S Rescoe, Ryan K Breuer, Mioko Kasagi, Vinay M Nadkarni, Akira Nishisaki, and National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).
• Pediatric Critical Care Medicine, Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ.
• Pediatr Crit Care Me. 2024 Feb 1; 25 (2): 147158147-158.

ObjectivesExtremes of patient body mass index are associated with difficult intubation and increased morbidity in adults. We aimed to determine the association between being underweight or obese with adverse airway outcomes, including adverse tracheal intubation (TI)-associated events (TIAEs) and/or severe peri-intubation hypoxemia (pulse oximetry oxygen saturation < 80%) in critically ill children.Design/SettingRetrospective cohort using the National Emergency Airway for Children registry dataset of 2013-2020.PatientsCritically ill children, 0 to 17 years old, undergoing TI in PICUs.InterventionsNone.Measurements And Main ResultsRegistry data from 24,342 patients who underwent TI between 2013 and 2020 were analyzed. Patients were categorized using the Centers for Disease Control and Prevention weight-for-age chart: normal weight (5th-84th percentile) 57.1%, underweight (< 5th percentile) 27.5%, overweight (85th to < 95th percentile) 7.2%, and obese (≥ 95th percentile) 8.2%. Underweight was most common in infants (34%); obesity was most common in children older than 8 years old (15.1%). Underweight patients more often had oxygenation and ventilation failure (34.0%, 36.2%, respectively) as the indication for TI and a history of difficult airway (16.7%). Apneic oxygenation was used more often in overweight and obese patients (19.1%, 19.6%) than in underweight or normal weight patients (14.1%, 17.1%; p < 0.001). TIAEs and/or hypoxemia occurred more often in underweight (27.1%) and obese (24.3%) patients ( p < 0.001). TI in underweight children was associated with greater odds of adverse airway outcome compared with normal weight children after adjusting for potential confounders (underweight: adjusted odds ratio [aOR], 1.09; 95% CI, 1.01-1.18; p = 0.016). Both underweight and obesity were associated with hypoxemia after adjusting for covariates and site clustering (underweight: aOR, 1.11; 95% CI, 1.02-1.21; p = 0.01 and obesity: aOR, 1.22; 95% CI, 1.07-1.39; p = 0.002).ConclusionsIn underweight and obese children compared with normal weight children, procedures around the timing of TI are associated with greater odds of adverse airway events.Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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