• Lancet · Mar 1971

    Orthotopic liver transplantation for Wilson's disease.

    • R S DuBois, D O Rodgerson, G Martineau, G Shroter, G Giles, J Lilly, C G Halgrimson, T E Starzl, I Sternlieb, and I H Scheinberg.
    • Lancet. 1971 Mar 13; 1 (7698): 505508505-8.

    AbstractAn 11-year-old boy with terminal hepatic failure due to Wilson’s disease was treated 18 months ago with orthotopic liver transplantation. Postoperatively, there has been evidence of clearance of body copper stores but without accumulation of copper in biopsy specimens of the transplanted liver after 6 and 17 months. Further follow-up will be necessary before deciding whether the disorder has been cured by liver replacement and in turn whether this constitutes proof that Wilson’s disease is an inborn error of hepatic metabolism. The observations so far are consistent with these conclusions.

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