• Internal medicine · Jul 2024

    Case Reports

    Discontinuing Hemodialysis through Corticosteroid Treatment in a Patient with Cryofibrinogen-associated Glomerulonephritis.

    • Shigeyuki Arai, Rena Matsui, Wataru Ono, Shinichiro Asakawa, Osamu Yamazaki, Yoshifuru Tamura, Mika Terasaki, Kanade Hagiwara, Tohru Nakagawa, Ryuji Ohashi, Akira Shimizu, Shigeru Shibata, and Yoshihide Fujigaki.
    • Department of Internal Medicine, Teikyo University School of Medicine, Japan.
    • Intern. Med. 2024 Jul 1; 63 (13): 189919051899-1905.

    AbstractCryofibrinogen-associated glomerulonephritis (CryoFiGN) is rare, and its diagnosis is difficult while treatment is not established. We herein report an elderly woman with CryoFiGN who experienced recurrent purpura and nephritic features that subsequently progressed to nephrotic syndrome and required hemodialysis during the 18-month clinical course. The patient was treated with corticosteroids, which led to the discontinuation of hemodialysis. The diagnosis of CryoFiGN was based on the clinical presentation, characteristic glomerular deposits, and results of laser microdissection and liquid chromatography-tandem mass spectrometry of the glomeruli. This case highlights the potential utility of corticosteroids as a treatment option for patients with CryoFiGN, even after hemodialysis.

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