• Jiwon Han, Jung-Hee Ryu, Young-Tae Jeon, and Chang-Hoon Koo.
• Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
• J. Cardiothorac. Vasc. Anesth. 2024 Jan 1; 38 (1): 141147141-147.

ObjectiveTo compare the effects of volatile anesthetics and propofol on neurocognitive function after cardiac surgery.DesignA systematic review and meta-analysis of randomized controlled trials.SettingA literature search of PubMed, EMBASE, CENTRAL, CINAHL, Scopus, and Web of Science databases was conducted.ParticipantsA total of 10 randomized controlled trials comparing volatile anesthetics and propofol in cardiac surgery were included in the study.InterventionsThe standardized mean difference and risk ratio were calculated to estimate pooled effect sizes.Measurements And Main ResultsThe primary outcome was the postoperative neurocognitive function score, and the secondary outcome was the incidence of delirium after cardiac surgery. The analysis did not show significant differences in postoperative neurocognitive function scores (standardized mean difference -0.06, 95% CI -0.81-0.69; p = 0.879). The incidences of delirium (risk ratio 1.10, 95% CI 0.81-1.50) between the volatile anesthetics and propofol groups were not significant (p = 0.533).ConclusionsUnlike noncardiac surgery, there are no differences between volatile anesthetics and propofol regarding postoperative neurocognitive dysfunction after cardiac surgery.Copyright © 2023 Elsevier Inc. All rights reserved.

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