• Phyllis L Carr, Michael B Rothberg, Robert H Friedman, Donna Felsenstein, and Joseph S Pliskin.
• Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. plcarr@bu.edu
• J Gen Intern Med. 2005 Sep 1; 20 (9): 793799793-9.

BackgroundAlthough vaginitis is a common outpatient problem, only 60% of patients can be diagnosed at the initial office visit of a primary care provider using the office procedures of pH testing, whiff tests, normal saline, and potassium hydroxide preps.ObjectiveTo determine the most cost-effective diagnostic and treatment approach for the medical management of vaginitis.DesignDecision and cost-effectiveness analyses.ParticipantsHealthy women with symptoms of vaginitis undiagnosed after an initial pelvic exam, wet mount preparations, pH, and the four criteria to diagnose bacterial vaginosis.SettingGeneral office practice.MethodsWe evaluated 28 diagnostic strategies comprised of combinations of pH testing, vaginal cultures for yeast and Trichomonas vaginalis, Gram's stain for bacterial vaginosis, and DNA probes for Neisseria gonorrhoeae and Chlamydia. Data sources for the study were confined to English language literature.MeasurementThe outcome measures were symptom-days and costs.ResultsThe least expensive strategy was to perform yeast culture, gonorrhoeae and Chlamydia probes at the initial visit, and Gram's stain and Trichomonas culture only when the vaginal pH exceeded 4.9 (330 dollars, 7.30 symptom days). Other strategies cost 8 dollars to 76 dollars more and increased duration of symptoms by up to 1.3 days. In probabilistic sensitivity analysis, this strategy was always the most effective strategy and was also least expensive 58% of the time.ConclusionsFor patients with vaginitis symptoms undiagnosed by pelvic examination, wet mount preparations and related office tests, a comprehensive, pH-guided testing strategy at the initial office visit is less expensive and more effective than ordering tests sequentially.

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