• Int J Med Sci · Jan 2023

    Review

    Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications.

    • Ni An, Zhe Chen, Peng Zhao, and Wen Yin.
    • Department of Emergency, Xijing Hospital, Air Force Medical University, Xi'an, China.
    • Int J Med Sci. 2023 Jan 1; 20 (13): 172217311722-1731.

    AbstractDespite significant advances in anti-infective treatment and organ function support technology in recent years, the mortality rate of sepsis remains high. In addition to the high costs of sepsis treatment, the increasing consumption of medical resources also aggravates economic pressure and social burden. Extracellular vesicles (EVs) are membrane vesicles released from different types of activated or apoptotic cells to mediate intercellular communication, which can be detected in both human and animal body fluids. A growing body of researches suggest that EVs play an important role in the pathogenesis of sepsis. In this review, we summarize the predominant roles of EVs in various pathological processes during sepsis and its related organ dysfunction.© The author(s).

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