• Yangyang Li, Teng Ye, Qianru Gu, Lei Dong, Guorong Chen, and Shanshan Lu.
• Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University Department of Dermatology, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou Children's Hospital, Wenzhou, Zhejiang Department of Pathology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• Medicine (Baltimore). 2018 Jan 1; 97 (1): e9543e9543.

RationalePrimary cardiac osteosarcoma is a rare tumor. To our knowledge, only 15 cases have been reported in the literature in the past 10 years. We describe a case of primary, cardiac, fibroblastic osteosarcoma in a 42-year-old woman.Patient ConcernsA 42-year-old woman with a 10-day history of chest pain. Intraoperatively, a mass was found originating from the ostium of the left inferior pulmonary vein in the left atrium, extending to the mitral orifice. Histologically, the tumor contained variable amounts of spindle cells and osseous differentiation in different areas. Primary, cardiac fibroblastic osteosarcoma had the typical appearance of interlacing hyperchromatic spindle-shaped stromal cells associated with osseous matrix.DiagnosesAccording to the clinicopathological features, diagnosis of primary, cardiac fibroblastic osteosarcoma was made.InterventionsWide surgical excision of the mass was performed.OutcomesThree months after the operation, transthoracic echocardiography demonstrated a 3.2 cm × 2 cm recurrent mass in the wall of the left atrium (LA). She died shortly afterwards as a result of the local disease recurrence.LessonsIn this report, we describe a rare case of primary, cardiac fibroblastic osteosarcoma, and findings are helpful for the pathologists would like to further identify the clinicopathological features of this rare tumor.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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