• Claudia Mehler-Wex and Michael Kölch.
• Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie, Universität Ulm. Steinhövelstrasse 5, Ulm, Germany. claudia.mehler-wex@uniklinik-ulm.de
• Dtsch Arztebl Int. 2008 Feb 1; 105 (9): 149155149-55.

IntroductionPrevalence rates for depression in children and adolescents are estimated up to 8.9%. Symptoms in this age group are different from those of depression in adults. Both neurobiological and psychosocial factors are involved in its development.MethodsSelective literature review.ResultsOf note are both the high rate of spontaneous remissions in childhood (33%), and the high rate of depressions continuing into adulthood (80%). In addition far fewer evidence based treatments are available than for adults. Fluoxetine is currently the only medication licensed for use in children and adolescents for this indication. Tri- and tetracyclic antidepressants have not been shown in meta-analyses to be effective in children and adolescents. Most antidepressants lead to age related side effects, including attention deficit and in particular behavioral toxicity, which has to be taken seriously wherever there is a suicide risk.DiscussionThe treatment of depression in childhood and adolescence should be based on multimodal interventions including psychotherapy, including cognitive behavioral therapy, which has proven effectiveness, psychosocial interventions and medications in severe cases. Patients with severe depression, especially suicidal minors, should be treated in patients units.

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