• Jean-Baptist du Prel, Bernd Röhrig, and Maria Blettner.
• Institut für Medizinische Biometrie, Epidemiologie und Informatik, Johannes Gutenberg-Universität, Mainz, Germany. duprel@imbei.uni-mainz.de
• Dtsch Arztebl Int. 2009 Feb 1; 106 (7): 100105100-5.

IntroductionIn the era of evidence-based medicine, one of the most important skills a physician needs is the ability to analyze scientific literature critically. This is necessary to keep medical knowledge up to date and to ensure optimal patient care. The aim of this paper is to present an accessible introduction into critical appraisal of scientific articles.MethodsUsing a selection of international literature, the reader is introduced to the principles of critical reading of scientific articles in medicine. For the sake of conciseness, detailed description of statistical methods is omitted.ResultsWidely accepted principles for critically appraising scientific articles are outlined. Basic knowledge of study design, structuring of an article, the role of different sections, of statistical presentations as well as sources of error and limitation are presented. The reader does not require extensive methodological knowledge. As far as necessary for critical appraisal of scientific articles, differences in research areas like epidemiology, clinical, and basic research are outlined. Further useful references are presented.ConclusionBasic methodological knowledge is required to select and interpret scientific articles correctly.

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