• Annals of Saudi medicine · Nov 2010

    Case Reports

    Craniopharyngioma in a patient with acromegaly due to a pituitary macroadenoma.

    • Hazem El-Bilbeisi, Mohammad Ghannam, Caramella F Nimri, and Azmi T Ahmad.
    • National Center for Diabetes, Endocrinology, Genetics, Amman, Jordan. elbilbeisi@hotmail.com
    • Ann Saudi Med. 2010 Nov 1; 30 (6): 485488485-8.

    AbstractWe present the first reported case of a craniopharyngioma as a second primary tumor in a patient with acromegaly due to a growth hormone (GH)-secreting pituitary adenoma. The patient was lost for follow-up for 18 years after trans-sphenoidal pituitary surgery for a GH-secreting pituitary adenoma. She presented with headaches and decreased visual acuity, and showed unsuppressed GH in an oral glucose load test with high IGF-1 levels. Brain MRI showed a suprasellar cystic mass and the patient underwent surgery for cyst drainage resulting in postoperative improvement in her vision. Biopsy of the mass confirmed the diagnosis of a craniopharyngioma. We stress the need for close follow-up of patients with acromegaly with adequate control of GH and IGF-1 levels.

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