Local injections of botulinum toxin type A have been used to treat essential head tremor but have not been extensively studied in randomized trials. ⋯ Injection of botulinum toxin into each splenius capitis muscle on day 0 and during week 12 was more effective than placebo in reducing the severity of isolated or essential head tremor at 18 weeks but not at 24 weeks, when the effects of injection might be expected to wane, and was associated with adverse events. (Funded by the French Ministry of Health; Btx-HT ClinicalTrials.gov number, NCT02555982.).
Ana Marques, Bruno Pereira, Marion Simonetta-Moreau, Giovanni Castelnovo, Marie De Verdal, Frédérique Fluchère, Chloé Laurencin, Bertrand Degos, Mélissa Tir, Alexandre Kreisler, Geneviève Blanchet-Fourcade... more , Dominique Guehl, Olivier Colin, Aurelia Poujois, Sophie Sangla, Laurent Tatu, Philippe Derost, Dominique Gayraud, Christine Tranchant, David Amarantini, David Devos, Olivier Rascol, Jean-Christophe Corvol, Franck Durif, Isabelle Rieu, and Btx-HT Study Group. less
From the Department of Neurology, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Université Clermont-Auvergne, Centre National de la Recherche Scientifique (CNRS), Image Guided Clinical Neuroscie... more nces and Connectomics, Institut Pascal (A.M., P.D., F.D., I.R.), and CHU Clermont-Ferrand, Clinical Research Department, Biostatistics Unit (B.P.), Clermont-Ferrand, the Clinical Investigation Center 1436, the Departments of Clinical Pharmacology, Physiology, and Neurosciences, Toulouse NeuroImaging Center, INSERM, University Hospital of Toulouse and University of Toulouse 3 (M.S.-M., O.R.), and Toulouse NeuroImaging Center, Université de Toulouse, INSERM, Université Paul Sabatier (D.A.), Toulouse, Service de Neurologie, CHU Caremeau, Nîmes (G.C., M.D.V.), the Department of Neurology and Movement Disorders, Timone Hospital, Aix-Marseille Université, Marseille (F.F.), Université de Lyon, Université Claude Bernard Lyon 1, Lyon Neuroscience Research Center, INSERM, Unité 1028, CNRS, Unité Mixte de Recherche (UMR) 5292, Neuroplasticity and Neuropathology of Olfactory Perception Team, Service de Neurologie C, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon (C.L.), the Neurology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires de Paris-Seine Saint Denis, Sorbonne Paris Nord, Bobigny (B.D.), Centre de Recherche Interdisciplinaire en Biologie, Collège de France, CNRS UMR 7241, INSERM Unité 1050, Université PSL (B.D.), the Neurology Department (A.P.) and Unité Parkinson (S.S.), Rothschild Foundation Hospital, and Sorbonne Université, Institut du Cerveau et de la Moelle, INSERM, CNRS, Assistance Publique-Hôpitaux de Paris, and the Department of Neurology, Hôpital Pitié-Salpêtrière (J.-C.C.), Paris, the Departments of Neurology and Neurosurgery, Expert Center for Parkinson's Disease, EA 4559 Laboratoire de Neurosciences Fonctionnelles et Pathologie, University of Picardy Jules Verne, Amiens University Hospital, Amiens (M.T., D.D.), the University of Lille, Lille Neuroscience and Cognition, Team DVCD, INSERM Unité Mixte de Recherche en Santé 1172, CHU Lille, Department of Medical Pharmacology, Expert Center of Parkinson's Disease, Lille Center of Excellence for Neurodegenerative Disorders, Centers of Excellence in Neurodegeneration, Lille (A.K.), Service de Neurologie, Narbonne Hospital Centre, Narbonne (G.B.-F.), CHU de Bordeaux, Institut des Maladies Neurodégénératives, CNRS, University of Bordeaux, Bordeaux (D. Guehl), the Department of Neurology, University Hospital of Poitiers, INSERM, CHU de Poitiers, University of Poitiers, Centre d'Investigation Clinique 1402, Poitiers (O.C.), the Department of Neuromuscular Diseases and Department of Anatomy, CHRU Besançon, University of Franche-Comté, Besançon (L.T.), Service de Neurologie, Centre Hospitalier Intercommunal Aix-Pertuis, Site d'Aix-en-Provence, Aix-en-Provence (D. Gayraud), and the Department of Neurology, CHU Hautepierre, INSERM Unité 964, CNRS UMR 7104, Illkirch, and Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg (C.T.) - all in France. less
N. Engl. J. Med. 2023 Nov 9; 389 (19): 175317651753-1765.