• Syedah Fauzia Fatima Gilani, Shabana Ali, Muhammad Bilal Siddique, Kulsoom Farhat, Mudassar Noor, and Farzana Waqar.
• Syedah Fauzia Fatima Gilani, MBBS, MPhil, Pharmacology Department, Army Medical College, Rawalpindi, Pakistan.
• Pak J Med Sci. 2023 Nov 1; 39 (6): 169517001695-1700.

ObjectiveTo evaluate the influence of dapagliflozin on renal functions and diuretics use in patients with acute heart failure (AHF).MethodsThis comparative analytical study was conducted at Armed Forces Institute of Cardiology, Rawalpindi from July 2022 to November 2022. Patients were distributed equally in two groups i.e. Dapagliflozin and Conventional Groups, where patients received dapagliflozin added to conventional therapy for AHF and, only conventional therapy for AHF respectively. Estimated glomerular filtration rate (eGFR), serum creatinine were measured and compared on admission, after 48 hours and on discharge. Weight loss during hospitalization, daily dose of furosemide and length of hospital stay was also recorded. Quantitative parameters were analyzed using t-test or Mann Whitney U test accordingly.ResultsThere were no significant baseline differences in renal functions. A modest decline in eGFR was observed in both groups after 48 hours. However, the variation in values of eGFR remained similar among both groups after 48 hours (p-value 0.365) and on discharge (p-value 0.768). Whereas, patients subjected to dapagliflozin treatment exhibited a more profound diuretic response expressed as greater weight loss (p-value < 0.001), achieved at comparatively lower doses of loop diuretics. Moreover, they also had a shorter duration of hospital stay (six vs eight days, p-value <0.001).ConclusionInstitution of dapagliflozin did not cause any significant deterioration of renal functions, whereas; it was associated with improved diuretic response as depicted by more pronounced weight loss at comparatively lower doses of loop diuretics.Copyright: © Pakistan Journal of Medical Sciences.

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