• Pak J Med Sci · Nov 2023

    Case Reports

    Lamotrigine-associated toxic epidermal necrolysis.

    • Omair Farooq, Akifa Abbas, Muhammad Ahmad, and Abu Bakr Manzoor.
    • Omair Farooq Assistant Professor, Medicine Department, Farooq Hospital, Lahore, Pakistan.
    • Pak J Med Sci. 2023 Nov 1; 39 (6): 188318861883-1886.

    AbstractToxic Epidermal Necrolysis (TEN) is an uncommon, idiosyncratic, potentially fatal dermatologic emergency affecting skin and mucous membranes. It is characterized clinically by blistering and widespread exfoliation, and pathologically by apoptosis of keratinocytes and epidermal necrosis. Drugs are one of the most common causative agents. The management ranges from nutritional support, care of denuded skin and mucosa to intravenous immunoglobulins (IVIG). The patient being reported developed TEN, secondary to lamotrigine; an anti-epileptic drug also used for bipolar disorder. On admission, lamotrigine was discontinued, he was managed symptomatically and given IVIG for three days. His condition started to improve after the first dose and he got discharged on 6th day of admission.Copyright: © Pakistan Journal of Medical Sciences.

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