Pathology of Primary Angiitis of the Central Nervous System.

Neuroimaging Clin. N. Am. · Feb 2024

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Pathology of Primary Angiitis of the Central Nervous System.

Primary angiitis of the central nervous system (PACNS) is a rare and potentially severe form of vasculitis that is limited to the brain, spinal cord, and meninges. Despite extensive research, the etiology and underlying immunologic mechanisms of PACNS remain largely unknown. PACNS presents with a variety of clinical, radiological, and pathologic features, but it is generally characterized by inflammation and destruction of the walls of blood vessels in the CNS, which can lead to tissue ischemia and/or hemorrhage. Three main histopathologic patterns have been identified, namely granulomatous, lymphocytic, and necrotizing vasculitis.

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- Selima Siala, Nabil Rahoui, Benjamin Cho, and Carlos A Zamora.
- Department of Radiology, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27514, USA. Electronic address: selima_siala@med.unc.edu.
- Neuroimaging Clin. N. Am. 2024 Feb 1; 34 (1): 313731-37.
AbstractPrimary angiitis of the central nervous system (PACNS) is a rare and potentially severe form of vasculitis that is limited to the brain, spinal cord, and meninges. Despite extensive research, the etiology and underlying immunologic mechanisms of PACNS remain largely unknown. PACNS presents with a variety of clinical, radiological, and pathologic features, but it is generally characterized by inflammation and destruction of the walls of blood vessels in the CNS, which can lead to tissue ischemia and/or hemorrhage. Three main histopathologic patterns have been identified, namely granulomatous, lymphocytic, and necrotizing vasculitis.Copyright © 2023 Elsevier Inc. All rights reserved.

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Pathology of Primary Angiitis of the Central Nervous System.

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