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Curr Gastroenterol Rep · Jun 2012
ReviewManagement and prognosis of acute liver failure in children.
- Daniel D'Agostino, Silvia Diaz, Maria Camila Sanchez, and Gustavo Boldrini.
- Gastroenterology-Hepatology Division, Liver-Intestinal Transplantation Center, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. daniel.dagostino@hiba.org.ar
- Curr Gastroenterol Rep. 2012 Jun 1;14(3):262-9.
AbstractAlthough the etiologies of pediatric acute liver failure (ALF) are diverse, ultimate pathophysiologic pathways and management challenges for these disorders, usually lethal in the pre-transplant era, are similar. This review considers particularly the mechanisms of, and monitoring for, intracranial hypertension and coagulopathy; summarizes detailed advice for management of the ALF-associated failures of multiple body systems; and reviews the variety of prognostic scores available to guide management and assist in choosing the patients most apt to benefit from liver transplantation and the optimal timing for such transplantation.
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