• Rev Med Interne · Jan 2024

    Case Reports

    [Severe systemic vasculitis induced by ibrutinib].

    • M Fenot, P Woaye Hune, S Vigouroux, G Veyrac, and C Poiraud.
    • Dermatologie, CHD Vendée, Les Oudairies, boulevard Stéphane-Moreau, 85925 La-Roche-sur-Yon, France. Electronic address: marion.fenot@ght85.fr.
    • Rev Med Interne. 2024 Jan 1; 45 (1): 131613-16.

    IntroductionThe specific cutaneous toxicity of Bruton's tyrosine kinase inhibitors is poorly described. We report a case of severe systemic vasculitis induced by ibrutinib.ObservationA 73-year-old woman with chronic lymphocytic leukemia was treated with ibrutinib. Eighteen months after treatment onset, ulceronecrotic lesions on toes and tongue occurred. Skin biopsy found vasculitis of small and medium vessels. Biologic tests were negative. This vasculitis was refractory to systemic corticosteroid therapy and azathioprine. Ibrutinib was stopped on the hypothesis of drug-induced vasculitis. Skin lesions improved after discontinuation of ibrutinib.ConclusionThe mechanism of action of ibrutinib does not explain the occurrence of vasculitis and an immunoallergic mechanism is suspected.Copyright © 2023 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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