• Eur. J. Clin. Invest. · Mar 2024

    Whole blood viscosity is associated with reduced myocardial mechano-energetic efficiency in nondiabetic individuals.

    • Alessia Riccio, Chiara M A Cefalo, Camilla Mazzanti, Laura Vero, Teresa Vanessa Fiorentino, Mattia Massimino, Giuseppe Monea, Elena Succurro, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, and Giorgio Sesti.
    • Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
    • Eur. J. Clin. Invest. 2024 Mar 1; 54 (3): e14127e14127.

    IntroductionThis cross-sectional study aimed to investigate the association between myocardial mechano-energetic efficiency (MEE) and whole blood viscosity (WBV) in nondiabetic adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study.Methods1143 participants underwent an oral glucose tolerance test and an echocardiogram for myocardial MEE per gram of left ventricular mass (MEEi) measurement. WBV was measured as: [0.12 × h] + [0.17 × (p-2.07)], where h is haematocrit and p is plasma protein levels.ResultsStudy population includes 595 males and 548 females with a mean age of 46 ± 12 years and a mean BMI of 30.0 ± 6.2 kg/m2 . Individuals with normal glucose tolerance were 63%, while those with impaired fasting glucose, impaired glucose tolerance and or the combination of both were 14.3%, 13% and 9.7%, respectively. A univariate analysis showed that MEEi was significantly associated with sex, age, smoking, BMI, waist circumference, total cholesterol, HDL, triglycerides, fasting glucose, fasting insulin, HOMA-IR index, glucose tolerance, C-reactive protein, haematocrit, haemoglobin, plasma protein and WBV. In a multivariable regression model including variables that were significantly associated with MEEi in univariate analysis, MEEi was associated with HOMA-IR (β = -0.144, p < .001), age (β = -0.140, p < .001), WBV (β = -0.129, p < .001) and glucose tolerance (β = -0.064, p = .04). The independent association between WBV and MEEi remained statistically significant (β = -0.122, p < .001) when antihypertensive therapy and lipid-lowering therapy were included in the model.ConclusionWBV is associated with decreased myocardial MEE independently of other cardiovascular risk factors.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

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