• Medicine · Jan 2018

    Efficacy, safety, and mechanisms of herbal medicines used in the treatment of obesity: A protocol for systematic review.

    • Moloud Payab, Shirin Hasani-Ranjbar, Azadeh Aletaha, Nasrin Ghasemi, Mostafa Qorbani, Rasha Atlasi, Mohammad Abdollahi, and Bagher Larijani.
    • Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Evidence Based Practice Research Center, Endocrinology and Metabolism Clinical Sciences Institute Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    • Medicine (Baltimore). 2018 Jan 1; 97 (1): e8825e8825.

    IntroductionThis systematic review protocol aims to perform a protocol for assessing the effectiveness, safety, and mechanism of herbal medicines for the treatment of obesity and metabolic syndrome. Some systematic reviews conducted earlier have evaluated the efficacy of herbal medicine to treat obesity and metabolic syndrome. Owing to the huge burden imposed by obesity in the recent years, a need is felt for conducting new systematic reviews on the topic of obesity with a focus on randomized clinical trials, we felt the need.Methods And AnalysisAll relevant clinical trials that examine the effectiveness of herbal medicines for the treatment of obesity and metabolic syndrome without restrictions on publication status will be applied.Four electronic databases will be searched: PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials. The main outcome is expected to be an improvement in the body weight, body mass index, waist circumference, waist-to-hip ratio, body fat (weight or mass of visceral adipose tissue, fat mass or percent), and appetite.Selection studies, data extraction, and risk of bias will be assessed independently by 2 authors.Ethics And DisseminationIn this study, ethical approval is not required because the data that will be used are not subjects and the results will be discussed through peer-reviewed publications.Trial Registration NumberPROSPEROCRD42016049753.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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