• Nicholas Van Halm-Lutterodt, J Alex Albright, Nicholas Robert Storlie, Mohamed Kamal Mesregah, Kashif Ansari, Mariah Balmaceno-Criss, Mohammad Daher, Mercy Bartels-Mensah, Yulun Xu, Bassel G Diebo, Yong Hai, David Ray Chandler, and Alan H Daniels.
• Department of Orthopedics Surgery, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA; School of Public Health and Professional Studies, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Orthopedics Surgery, Keck Medical Center of the University of Southern California, Los Angeles, California, USA.
• World Neurosurg. 2024 Jan 1; 181: e1001e1011e1001-e1011.

ObjectiveThe aim of this study, a retrospective database analysis, was to assess the impact of baseline cannabis use disorder (CUD) on perioperative complication outcomes in patients undergoing primary 1- to 2-level anterior cervical diskectomy and fusion (ACDF) surgery.MethodsThe PearlDiver Database was queried from January 2010 to December 2021 for patients who underwent primary 1- to 2-level ACDF surgery for degenerative spine disease. Patients with CUD diagnosis 6 months before the index ACDF surgery (i.e., CUD) were propensity matched with patients without CUD (i.e., control in a ratio of 1:1, employing age, gender, and Charlson Comorbidity Index as matching covariates). Univariate and multivariable analysis models with adjustment of confounding variables were used to evaluate the risk of CUD on perioperative complications between the propensity-matched cohorts.ResultsThe 1:1 matched cohort included 838 patients in each group. Following multivariate analysis, CUD was demonstrated to be associated with an increased incidence of hospital readmission at 90 days (odds ratio [OR] = 2.64, 95% confidence interval: [1.19 to 6.78], [P = 0.027]) and revision surgery at 1 year postoperative (OR = 3.36, 95% confidence interval: [1.17 to 14.18], [P = 0.049]). CUD was additionally associated with reduced risk of overall medical complications at both 6 months and 1 year postoperative (OR = 0.55, [P = 0.021], and OR = 0.54, [P = 0.015], respectively).ConclusionsThese findings indicate that isolated baseline CUD is associated with an increased risk of hospital readmission at 90 days postoperative and cervical spine reoperation at 1 year after primary 1- to 2-level ACDF surgery with a decrease in overall medical complications, cardiac arrhythmias, and acute renal failure.Copyright © 2023 Elsevier Inc. All rights reserved.

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