• Critical care clinics · Jan 2024

    Review

    Design and Execution of Clinical Trials in the Cardiac Intensive Care Unit.

    • Jacob B Pierce, Willard N Applefeld, Balimkiz Senman, Daniel B Loriaux, Patrick R Lawler, and Jason N Katz.
    • Department of Internal Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: Jacob.pierce@duke.edu.
    • Crit Care Clin. 2024 Jan 1; 40 (1): 193209193-209.

    AbstractClinical practice in the contemporary cardiac intensive care unit (CICU) has evolved significantly over the last several decades. With more frequent multisystem organ failure, increasing use of advanced respiratory support, and the advent of new mechanical circulatory support platforms, clinicians in the CICU are increasingly managing patients with complex comorbid disease in addition to their high-acuity cardiovascular illnesses. Here, the authors discuss challenges associated with traditional trial design in the CICU setting and review novel clinical trial designs that may facilitate better evidence generation in the CICU.Copyright © 2023 Elsevier Inc. All rights reserved.

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