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- Shinichi Okuzumi, Hiraku Suzuki, Shojiroh Morinaga, Masaki Tamura, and Naoto Minematsu.
- Department of Medicine, Hino Municipal Hospital, Japan.
- Intern. Med. 2024 Jun 15; 63 (12): 178917951789-1795.
AbstractMesenchymal-epithelial transition (MET) exon 14-skipping mutation (METex14) is rare in pulmonary invasive mucinous adenocarcinomas (IMAs), and the clinical impact of MET-tyrosine kinase inhibitors (TKIs) remains unknown. We herein report a 75-year-old woman with IMA harboring METex14 who was treated with the MET-TKI tepotinib. The lung tumor regressed over six months; however, the patient ultimately died of exacerbated interstitial lung disease (ILD), possibly associated with tepotinib. An autopsy revealed diffuse alveolar damage in pre-existing chronic fibrosis. We discuss how to pre-evaluate ILD deterioration risks and monitor TKI-induced lung toxicity during treatment.
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