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- Kento Shionoya, Masahiro Kobayashi, Makoto Kako, Sakue Masuda, Makomo Makazu, and Kazuya Koizumi.
- Gastroenterology Medicine Center, Shonan Kamakura General Hospital, Japan.
- Intern. Med. 2024 Jun 15; 63 (12): 171917231719-1723.
AbstractVanishing bile duct syndrome (VBDS) is characterized by bile duct degeneration and necrosis, which result in bile duct loss and bile stasis. A 70-year-old man had malaise after receiving celecoxib. Laboratory tests revealed elevated hepatobiliary enzymes. His condition worsened without response to medical treatment, and he was transferred to our hospital. A liver biopsy revealed severe bile duct injury and mild cholestasis. He was diagnosed with celecoxib-induced VBDS and underwent bilirubin adsorption therapy. However, his condition continued to deteriorate, and he died. An autopsy showed that liver regeneration was poor, and bile duct loss was exacerbated. The pathological autopsy findings were consistent with VBDS.
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