• Internal medicine · Jun 2024

    Case Reports

    Organizing Pneumonia in a Case of cold Agglutinin Disease with Pulmonary Thrombosis.

    • Yuki Yabuuchi, Yuko Minami, Akihiro Kuroda, Norimasa Ooba, Takashi Matsuda, Jun Kanazawa, Yukiko Miura, Shingo Usui, Shuji O-Ishi, Kenji Hayashihara, Takefumi Saito, and Nobuyuki Hizawa.
    • Department of Pulmonary Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan.
    • Intern. Med. 2024 Jun 15; 63 (12): 180118061801-1806.

    AbstractCold agglutinin disease is a subtype of autoimmune hemolytic anemia that occurs via the activation of specific anti-red blood cell antibodies (agglutinins) at low temperatures. Autoimmune hemolytic anemia has been reported to cause interstitial pneumonia; however, the underlying mechanism remains unclear. We herein report a 46-year-old man diagnosed with cold agglutinin disease complicated by pulmonary thrombosis and organizing pneumonia. Treatment with prednisolone improved the course of cold agglutinin disease and organizing pneumonia in a similar manner. To our knowledge, this is the first report of cold agglutinin associated with organizing pneumonia, suggesting a potential link between the two.

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