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Case Reports
Macitentan Administration for Pulmonary Hypertension Due to β-thalassemia with Multiple Organ Failure: A Case Report.
- Kento Takagi, Hajime Kasai, Hiroyuki Tani, Seiichiro Sakao, Toshihiko Sugiura, and Takuji Suzuki.
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan.
- Intern. Med. 2024 Jun 1; 63 (11): 158515901585-1590.
AbstractA 51-year-old Thai woman diagnosed with β-thalassemia underwent regular blood transfusion and iron-chelating therapy. However, after voluntarily discontinuing treatment, the patient developed progressive dyspnea and was diagnosed with pulmonary hypertension following right heart catheterization. Despite resuming blood transfusions, her condition did not improve. Because the patient had a history of multiple organ failure, curative treatment for β-thalassemia was not feasible, and macitentan was administered. Despite experiencing hypotension as an adverse event, her condition remained stable during macitentan treatment. Thus, macitentan may be well tolerated in patients with pulmonary hypertension caused by β-thalassemia with multiple organ dysfunction.
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