• John T Chibnall, Raymond C Tait, Bonnie Harman, and Rebecca A Luebbert.
• Department of Psychiatry, School of Medicine, Saint Louis University, St. Louis, Missouri 63104, USA. chibnajt@slu.edu
• J Am Geriatr Soc. 2005 Nov 1;53(11):1921-9.

ObjectivesTo evaluate the effect of regularly scheduled administration of analgesic medication on behavior, emotional well-being, and use of as-needed psychotropic medications in nursing home residents with moderate-to-severe dementia.DesignRandomized, double-blind, placebo-controlled, crossover trial.SettingNursing-home based.ParticipantsTwenty-five nursing home residents with moderate-to-severe dementia.InterventionParticipants received 4 weeks of acetaminophen (3,000 mg/d) and 4 weeks of placebo.MeasurementsBehavior and emotional well-being were assessed using Dementia Care Mapping, an observational method that quantifies time spent in behaviors across 26 domains (e.g., social interaction, unattended distress) and assesses emotional state while behaviors are being observed. Agitation was measured using the Cohen-Mansfield Agitation Inventory. As-needed psychotropic medication use was aggregated from medication logs.ResultsParticipants spent more time in social interaction, engaged with media, talking to themselves, engaged in work-like activity, and experiencing unattended distress when they received acetaminophen than they did when they received placebo. Participants also spent less time in their rooms, less time removed from the nursing home unit, and less time performing personal care activities when they received acetaminophen. There were no effects on agitation, emotional well-being, or as-needed psychotropic medication use.ConclusionUntreated pain inhibits activity in nursing home residents with moderate-to-severe dementia. Pain treatment in this group may facilitate engagement with the environment.

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