• Elham Rahmanian, Nader Tanideh, Saied Karbalay-Doust, Davood Mehrabani, Davood Rezazadeh, Deniz Ketabchi, Narges EskandariRoozbahani, Nasrin Hamidizadeh, Farzad Rahmanian, and Mohammad Reza Namazi.
• Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, And Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
• Burns. 2024 Apr 1; 50 (3): 630640630-640.

BackgroundMagnesium (Mg) is an essential factor in the healing process. This study aimed to evaluate the effect of Mg creams on healing burn wounds in the rat model.MethodsTo induce burns under general anaesthesia, a 2 × 2 cm2, 100 °C plate was placed for 12 s between the scapulas in 100 male adult Sprague Dawley rats. Animals were divided into five groups (n = 20); positive control (induced burn without treatment); vehicle control (received daily Eucerin cream base topically); comparative control (induced burn and treated daily with Alpha burn cream topically); Treatment 1 and 2 (received daily Mg cream 2% and 4% topically, respectively). All animals were bled for hematological assessment of malondialdehyde (MDA) and TNF-α and sacrificed on days 0, 1, 7, 14, and 21 after interventions for biomechanical, histological, and stereological studies.ResultsStereologically speaking, in treatment groups an increase in dermal collagen volume and fibroblasts was noticed. In treatment groups, the length of vessels, angiogenesis, and skin stretch increased, but the wound area, MDA, and TNF-α level decreased.ConclusionMg cream was effective in healing burns.Copyright © 2023 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.

14 keywords...

hide…